Case report: PANDAS and persistent Lyme disease with neuropsychiatric symptoms
Complete resolution of symptoms following IVIg and antimicrobial treatment
In this newly published article, the authors describe the diagnosis, symptom progression and treatment of a 7-year-old female with serological evidence of Lyme disease who developed multiple neuropsychiatric symptoms six months after visiting a tick endemic region.1 Prior to her diagnosis of Lyme disease, the patient had been treated for three distinct episodes of streptococcal pharyngitis and diagnosed with PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections).
Over a three-week period, the patient developed multiple symptoms including obsessions, compulsions, aggressive behavior, dramatic declines in cognitive functioning, loss of math skills, the onset of dysgraphia and difficulty with social cues, fatigue, nighttime awakening, chills, joint and muscle pain, moodiness, separation anxiety and panic attacks.
Following several months of oral and IV antimicrobial treatment, the Cunningham Panel™ of tests was ordered to assess the presence of antineuronal antibodies against specific neuronal receptors. Based upon test results, “the decision was made to prescribe intravenous immunoglobulin (IVIg) in accordance with established treatment guidelines for the patient’s level of symptom severity.”
“Over a span of 31 consecutive months of treatment with various antimicrobials and 3 courses of intravenous immunoglobulins (IVIg), she experienced complete remission and remains symptom free at the time of this publication.”
The authors conclude that “This patient’s case may be representative of numerous other cases of autoimmune neuropsychiatric illnesses where a patient may have concomitant infections and co-morbid diagnoses.”
“As evidenced by her recovery and resolution of symptoms, treating both the Lyme infection and streptococcal infection, as well as treating the underlying autoimmune etiology of her neuropsychiatric symptoms resulted in a successful outcome.”
Digital Information Packet
To learn more about infection-triggered basal ganglia encephalitis syndromes, such as PANS/PANDAS, view our online informational packet. We have compiled journal articles and video clips that may be helpful to you.
Lyme Disease and the Immune System: Elevated Neuronal Autoantibodies Associated with Persistent Symptoms
Cunningham Panel™ results indicate Lyme disease may trigger autoimmune dysfunction
Study Demonstrates Clinical Value of the Cunningham Panel™ and Accuracy in Patients with Symptoms of an Autoimmune Encephalopathy
Antineuronal antibodies correlate with pre- and post-treatment neuropsychiatric symptoms
Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections
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Learn more about how the Cunningham Panel™ of tests can assist you in diagnosing treatable autoimmune encephalopathies characterized by abnormal neuropsychiatric behaviors. Schedule your personal phone consultation with a Moleculera Labs clinical staff member by completing the form below.