A sudden onset or departure from the norm of any of these symptoms may indicate the presence of PANS and/or PANDAS:

Physical Symptoms of PANS and/or PANDAS:

  • Vocal/motor tics of any type, severity or duration
  • Sensory or motor abnormalities
  • Sleep disturbances
  • Enuresis/urinary issues
  • Anorexia

Behavioral Symptoms of PANS and/or PANDAS:

  • Personality changes at home or at school
  • Anxiety or unusual fears, separation anxiety
  • Emotional instability and/or depression
  • Irritability, aggression or rage
  • Oppositional/defiant behaviors
  • Behavioral or developmental regression
  • Deterioration in school performance
  • Obsessions/compulsions
  • Inability to concentrate
  • Impulsivity/distractibility
  • Worrying about harm
  • Changes in handwriting

These symptoms which are associated with a clinical diagnosis of PANS or PANDAS are discussed in detail on the “Information About PANDAS” on the NIMH website.  In more chronic cases, clinicians may see seemingly unrelated symptom clusters in the patient who is not responding to treatment as the clinician would expect.