Steroid treatment response to post SARS-CoV-2 PANS symptoms: Case series
This case series describes 10 children with an acute onset or relapse of symptoms related to Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) following a SARS-CoV-2 infection. 1 The authors assessed the efficacy of pulse treatment with steroids for 3 consecutive months.
Their findings suggest “the clinical presentation of the COVID-19-triggered PANS is largely similar to that reported in typical PANS, including acute onset, with OCD and/or eating disorders, and associated symptoms.”
Furthermore, “treatment with corticosteroids may be beneficial for both global clinical severity and global functioning. Both OCD symptoms and tics consistently improved.”
“The authors point out that “Among psychiatric symptoms, affective and oppositional symptoms appeared more sensitive to the steroid treatment than other symptoms.”
- “COVID-19 infection should be explored in children and adolescents with acute-onset neuropsychiatric disorders.”
- “… in children and adolescents with COVID-19, a specific neuropsychiatric follow-up should be routinely included in the clinical management of these young patients.”
- “… in patients with more severe and acute symptoms, corticosteroid treatment in the acute phase may be beneficial and well tolerated.”