Moleculera Labs Educational Series:

Steroid treatment response to post SARS-CoV-2 PANS symptoms: Case series

Steroid treatment response to post SARS-CoV-2 PANS symptoms

This case series describes 10 children with an acute onset or relapse of symptoms related to Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) following a SARS-CoV-2 infection. 1 The authors assessed the efficacy of pulse treatment with steroids for 3 consecutive months.

Their findings suggest “the clinical presentation of the COVID-19-triggered PANS is largely similar to that reported in typical PANS, including acute onset, with OCD and/or eating disorders, and associated symptoms.”

Furthermore, “treatment with corticosteroids may be beneficial for both global clinical severity and global functioning. Both OCD symptoms and tics consistently improved.”

“The authors point out that “Among psychiatric symptoms, affective and oppositional symptoms appeared more sensitive to the steroid treatment than other symptoms.”

Authors conclude:

  1. “COVID-19 infection should be explored in children and adolescents with acute-onset neuropsychiatric disorders.”
  2. “… in children and adolescents with COVID-19, a specific neuropsychiatric follow-up should be routinely included in the clinical management of these young patients.”
  3. “… in patients with more severe and acute symptoms, corticosteroid treatment in the acute phase may be beneficial and well tolerated.”

How can the Cunningham Panel™ help you in identifying and treating patients with infection-induced autoimmune encephalopathies?

  1. Berloffa S, Salvati A, Pantalone G, Falcioni L, Rizzi MM, Naldini F, Masi G, Gagliano A. Steroid treatment response to post SARS-CoV-2 PANS symptoms: Case series. Front Neurol. 2023 Feb 14;14:1085948. doi: 10.3389/fneur.2023.1085948. PMID: 36864920; PMCID: PMC9972432.