Dr. Gary Kaplan’s Patient Case

The parents have their kid back. He’s back attending school. He got his GED. He was not able to finish high school because he was so sick. But he went back and got his GED. Now, he’s at a community college. And he’s back to being his normal, sweet self.

WATCH VIDEO: DR. KAPLAN’S PATIENT CASE


Dr. Gary Kaplan, DO:

I had one patient who I treated. He was about 17 years old. He had been healthy, a great student in school. He was big on sports. And almost overnight, as the father said, it was like somebody threw a switch.

This kid changed dramatically. He's having rage attacks. Now, understand that this kid is the sweetest, most loving, wonderful kid. But he's having rage attacks. Rage attacks, where he has done thousands and thousands of dollars in damage to the house. Interestingly, he never attacks a person but he's put his fist through walls. He’s torn plate glass windows off. He's done a lot of damage to the house.

He also developed an eating disorder and body dysmorphia. He starts picking at his body. He’s starting to lose weight. He loses 10 lbs. He loses 20 lbs. He loses 30 lbs.

At that point, his pediatrician had decided that the problem was obsessive-compulsive disorder and body dysmorphia. So, he is hospitalized, psychiatrically.

And nothing is working. He comes to see me about 6 to 8 months later. And as I’m taking the history, I’m noticing very discreet episodes, these rage attacks, these issues where he can't walk for periods of time, this regressive behavior.

So, I thought this sounds more like seizure-type events. We see this in the PANS and PANDAS population. He’s older. But let's find out what's going on.

In checking him, we found that he actually had Lyme disease, Bartonella and Babesia. So, he had three bugs sitting in him.

But on the Cunningham Panel™, he's off the charts. The dopamine receptors are off. The CaMKinase is off.

So, we’ve got a real-time understanding of an autoimmune process going on, at the same time that we have these very serious infections.

We’ve treated him for the infections successfully. We are still addressing the autoimmune component of it with regular IVIG treatments.

However, the parents have their kid back. He's back attending school. He got his GED. He was not able to finish high school because he was so sick. But he went back and got his GED. Now, he’s at a community college. And he’s back to being his normal, sweet self.

So, this is a success story. And we see a lot of people like this. But we also see it in the adults. Now, adults don’t tend to show up quite as dramatically. But we'll see brain fog, focus and concentration issues, difficulty with remembering anything, as well as sleep disorders and chronic fatigue and generalized pain.

And when you see that kind of a big picture, inevitably you're dealing with an inflammatory process that involves both the innate and the acquired immune system.

Now, what’s ticking it off? We have to figure that out, as well. So, it's a matter of putting this whole picture together.

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Infections may result in developing PANDAS

LEARN MORE: AUTOIMMUNE NEUROPSYCHIATRIC DISORDERS

PANS: Diagnosis and Treatment

PANS/PANDAS Overview

PANDAS & PANS Patient Stories

PANDAS & PANS Patient Stories

Neuropsychiatric Symptoms

Neuropsychiatric Symptoms

  • Test Order Process
    The Cunningham Panel™ – Antibody testing that helps determine whether an autoimmune response may be triggering neurologic and/or psychiatric symptoms.

B. Robert Mozayeni, MD

Medical and Clinical Advisor

B. Robert Mozayeni MD

Dr. B. Robert Mozayeni was trained in Internal Medicine and Rheumatology at Yale and at NIH. He has had pre- and post-doctoral Fellowships in Molecular Biophysics and Biochemistry at Yale, and also at NIH where he was a Howard Hughes Research Scholar at LMB/DCBD/NCI and later, Senior Staff Fellow at LMMB/NHLBI/NIH. Editorial board of Infectious Diseases – Surveillance, Prevention and Treatment. Past President of the International Lyme and Associated Diseases Society (ILADS).

He is an expert in Translational Medicine, the science and art of advancing medical science safely and efficiently. He is a Fellow of the non-profit Think Lead Innovate Foundation and is a co-founder of the Foundation for the Study of Inflammatory Diseases. He is a Founder of the Foundation for the Study of Inflammatory Diseases to crowd-source medical solutions for complex conditions using existing knowledge, diagnostic methods, and therapies to meet patient needs immediately. He is the Chief Medical Officer of Galaxy Diagnostics, LLC. He is a Board member of the Human-Kind Alliance. Dr. Mozayeni has held admitting privileges (since 1994) on the clinical staff of Suburban Hospital, a member of Johns Hopkins Medicine and an affiliate of the National Institutes of Health Clinical Center.

Safedin Sajo Beqaj, PhD, HCLD, CC (ABB)

Moleculera Labs, Clinical Laboratory Advisor
Medical Database, Inc., President and CEO

Sajo Baqaj, PhD

Dr. Sajo Beqaj is board certified in molecular pathology and genetics and licensed as a Bioanalyst and High Complexity Laboratory Director. He has been practicing as a laboratory director since 2005.

Dr. Beqaj served as a technical director and was part of the initial management team for several well-known laboratories in the clinical lab industry including PathGroup, Nashville, TN; DCL Medical Laboratories, Indianapolis, IN, and Pathology, Inc, Torrance, CA. He is currently serving as off-side CLIA laboratory director for BioCorp Clinical Laboratory, Whittier, CA and Health360 Labs, Garden Grove, CA.

Dr. Beqaj received his Ph.D. in Pathology from Wayne State University Medical School, Detroit, Michigan. He performed his post-doctoral fellowship at Abbott Laboratories from 2001-2003 and with Children’s Hospital and Northwestern University from 2003-2005.

Dr. Beqaj has taught in several academic institutions and has published numerous medical textbook chapters and journal articles. He has served as a principal investigator in clinical trials for several well-known pharmaceutical and diagnostic companies such as Roche HPV Athena, Merck HPV vaccine, BD vaginitis panel, Roche (Vantana) CINtec® Histology clinical trials, and has presented various scientific clinical abstracts and presentations.

He is a member of several medical and scientific associations including the Association of Molecular Pathology, American Association of Clinical Chemistry and the Pan Am Society for Clinical Virology. He has served on a number of clinical laboratory regulatory and scientific committees, and has assisted several laboratories and physicians as a Clinical Laboratory Consultant.

Rodney Cotton, MBA

Moleculera Labs Board Member

Rodney Cotton, MBA

Rodney Cotton, MBA is an entrepreneurial thought leader in the pharmaceutical/biotech industry who is known for his holistic perspective, bias for action in the face of challenges, and commitment to agile processes.

Rod is an independent director for Orchard Software, a private equity-backed health technology company owned by Francisco Partners; an advisory board member to Flo2 Ventures, a venture capital-backed healthcare and health equity accelerator; and a member of the board of directors and three board committees (Audit, Compliance & Finance; Governance & Equity; and Quality of Care) for Community Health Network.

He built a successful career at Roche spanning more than two decades and culminating in the role of SVP, Head of Strategy & Transformation, and Chief of Staff to the CEO for Roche Diagnostics, the North American headquarters of the world’s largest ($17B) diagnostics company.

While at Roche, Rod led key enterprise initiatives, such as milestone corporate communications, health equity coalitions, the US/Roche Group audit, and global/US acquisition integrations. With 40+ years of experience, he drove the financial turnaround and cultural transformation of four global healthcare companies, led teams of up to 280 total reports, managed P&L of more than $1 billion, and served as a key member of the senior leadership team executing the most significant restructuring of the company in two decades.

In the face of the COVID-19 pandemic, Rod and his team at Roche accelerated six ground breaking products in 11 months, including the first launch of the market’s most accurate and in demand molecular diagnostic test. He also solved extraordinary challenges of product scarcity, supply chain, product allocation, and logistics to achieve accelerated global sourcing and self manufacturing in line with testing guidelines.

A frequent public speaker on health equity and other topics, Rod was named one of the Most Influential Black Executives in Corporate America by Savoy Magazine and one of the Top Blacks in Healthcare by BlackDoctor.org. He also received The Sagamore of the Wabash Award, one of the highest Indiana State honors, bestowed by Indiana Governor Eric J. Holcomb.

Rod holds an M.B.A. from California State University, Dominguez Hills, an M.S. in Strategic Management from the University of Southern California, and a B.A. in Biological Sciences & Technology from the University of California at Santa Barbara.